* Note: Prices are in Million (M) USD.
Description:
Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapies in the United States. The company is headquartered in Carlsbad, California.
These criteria used Company's Cash, EBITDA and Debt balance to determines its fair value:
Cash : $372 M
Debt : $1,802 M
EBITDA : $4,534 M
Net Debt (Debt - Cash): $1,430 M
Since Net Debt is covered by EBITDA within 1 year, 3 points assigned.
This criteria used industry in which company operates:
Sector: Healthcare
Industry: Biotechnology
Biotechnology detected → treating as non-Technology. 3 points assigned.
This criteria used Company's Price To Earning (P/E) Ratio to determines its fair value:
Message: Cannot calculate PE Ratio since EPS is either 0 or negative.
Using default values for calculation.
Forward PE Ratio (using default values): 20.00
Since Forward PE Ratio is between 20 - 25, 2 points assigned.
This criteria used Company's ability to convert Sales into free cash flow to determine fair value:
Using last 20 overlapping fiscal years (max 20).Average Free Cash Flow: $-34 M
Average Revenue: $420 M
Revenue Converted To Free Cash Flow (%): -8.1%
Since Free Cash Flow (FCF) to Revenue percentage is non-positive, 0 point assigned.
This criteria used company's growth potential to calculate its fair value:
Latest Revenue (2025-12-31): $944 M
Revenue 5 Years Ago (2020-12-31): $729 M
Total Growth over 5 Years: 29.5%
5-Year Revenue CAGR (Historical): 5.3%
Forward 5-Year CAGR (Tapered): 4.8%
Since historical Revenue CAGR is between 5 - 10, 2 points assigned.
This criteria used Company's ability to buy back its own share:
Latest Share Count (2025-12-31): $160 M
Share Count 5 Years Ago (2021-12-31): $141 M
Company is not buying back its own shares, 0 points assigned.
This criteria used Company's dividend payout ratio to determine its fair value:
Next Year Earnings Per Share (EPS): $-0.62
Trailing 12-Month Earnings Per Share (EPS): $-3.32
Average Earnings Per Share (EPS): $0.00
Dividend Per Share (DPS): $0
Payout Ratio: 0%
Dividend Yield: 0.00%
⚠️ Caution: Negative earnings detected — Further research is recommended - Next Fiscal Yr EPS: $-0.62
- Latest/TTM EPS: $-3.32
Since Dividend Per Share is less than or equal to 0, 0 point assigned.
Since Dividend Yield is less than 1, 0 point assigned.
This criteria used Company's Return On Equity (ROE%) to determine its fair value:
Using last 20 valid ROE years (max 20).Average ROE: -94.6%
Since Average ROE is non-positive, 0 point assigned.
This criteria used Company's current price to its 52 week low price to determines its fair value:
Current Price: $73.89
52-Week Low: $23.95
Threshold Price (15% Above 52-Week Low): $27.54
Since Current price is not within 15% threshold, 0 point assigned.
This criteria used Company's Market Cap to determines its fair value:
Market Capitalization: $12,279 M
Since Market Cap is between 10B - 100B, 2 points assigned.
% Exposure to Total Portfolio
Based on the market cap, we recommend do not exceed 3% exposure of Total Portfolio.
Warren Buffett's Owners' Earnings:
Owners' Earnings (FCF/Share, latest positive annual) (2021-12-31): $0.08
Note: Many fast-growing companies reinvest heavily, so Owners' Earnings may appear low.
Consider other factors in your valuation.
Value-Trade has assigned 12 points to above Ionis Pharmaceuticals Inc (IONS) stock.
Last 2 Years Avg PE 17.46, Fair Value PE 12, Industry Based PE 15, Growth Based PE 15, Risk-Free Anchored PE (25% MoS) 17.65. Based on these 5 values, average assigned is 15.42. The fair value of Ionis Pharmaceuticals Inc (IONS) stock cannot be calculated since EBITDA and EPS are either 0 or negative.
