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| Date | Name | Title | Action | No Shares | Price Per Share |
|---|---|---|---|---|---|
Insider Transactions For IONS | |||||
| 2026-06-26 | Monia, Brett P | Director, Chief Executive Officer | Sold | 50000 | $80.59 |
| 2026-06-26 | O'neil, Patrick R. | EVP CLO & General Counsel | Sold | 3069 | $80.00 |
| 2026-06-26 | Schneider, Eugene | EVP, Chf Clinical Develop Ofcr | Purchased | 26000 | $60.89 |
| 2026-06-26 | Schneider, Eugene | EVP, Chf Clinical Develop Ofcr | Sold | 26000 | $81.05 |
| 2026-06-26 | Schneider, Eugene | EVP, Chf Clinical Develop Ofcr | Sold | 26000 | $0.00 |
| 2026-06-26 | Monia, Brett P | Director, Chief Executive Officer | Purchased | 50000 | $56.78 |
| 2026-06-26 | Monia, Brett P | Director, Chief Executive Officer | Sold | 50000 | $0.00 |
| 2026-06-26 | Baroldi, Joseph | EVP, Chief Business Officer | Purchased | 3866 | $56.78 |
| 2026-06-26 | Baroldi, Joseph | EVP, Chief Business Officer | Purchased | 1769 | $32.60 |
| 2026-06-26 | Baroldi, Joseph | EVP, Chief Business Officer | Sold | 5635 | $80.16 |
| 2026-06-26 | Baroldi, Joseph | EVP, Chief Business Officer | Sold | 1769 | $0.00 |
| 2026-06-26 | Baroldi, Joseph | EVP, Chief Business Officer | Sold | 3866 | $0.00 |
| 2026-06-25 | Monia, Brett P | Director, Chief Executive Officer | Purchased | 21072 | $32.60 |
| 2026-06-25 | Monia, Brett P | Director, Chief Executive Officer | Sold | 21072 | $78.49 |
| 2026-06-25 | Swayze, Eric | EVP Research | Sold | 10602 | $79.18 |
| 2026-06-25 | Monia, Brett P | Director, Chief Executive Officer | Sold | 21072 | $0.00 |
| 2026-06-24 | Monia, Brett P | Director, Chief Executive Officer | Sold | 14565 | $78.41 |
| 2026-06-24 | Monia, Brett P | Director, Chief Executive Officer | Sold | 14565 | $0.00 |
| 2026-06-24 | Monia, Brett P | Director, Chief Executive Officer | Purchased | 14565 | $32.60 |
| 2026-06-15 | Berthelsen, Spencer R | Director | Purchased | 8000 | $24.42 |
